Radical scavenging action of MCI-186, a new antiischemic agent.
نویسندگان
چکیده
منابع مشابه
MCI-186 (edaravone), a novel free radical scavenger, protects against acute autoimmune myocarditis in rats.
In this study, we tested the hypothesis that MCI-186 (3-methyl-1-phenyl-2-pyrazolin-5-one; edaravone), a novel free radical scavenger, protects against acute experimental autoimmune myocarditis (EAM) in rats by the radical scavenging action associated with the suppression of cytotoxic myocardial injury. Recent evidence suggests that oxidative stress may play a role in myocarditis. We administer...
متن کاملEffect of MCI-186 on brain edema in rats.
We induced brain edema in 72 rats by injecting 5 microliters of 3.0% wt:vol polyvinyl acetate into the left internal carotid artery, producing permanent embolization in the left cerebral hemisphere, which developed ipsilateral brain edema reproducibly. Edema was assessed 24 hours after embolization by determining the brain water content and the sodium and potassium concentrations. In this model...
متن کاملEffects of MCI-186 (edaravone), a novel free radical scavenger, upon experimental atherosclerosis in apolipoprotein E-deficient mice.
BACKGROUND Recent evidence suggests that oxidative stress may play a role in the development of atherosclerosis. MCI-186 (3-methyl-1-phenyl-1-phyrazolin-5-one, edaravone) is a novel free radical scavenger, but it remains unclear whether free radical scavengers would be effective for the prevention of the disease. METHODS AND RESULTS Experimental atherosclerosis was induced in apolipoprotein E...
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Salvia reuterana Bioss. is an aromatic perennial plant traditionally used for its anxiolytic and sedative properties. In the present study, various fractions and essential oil of S. reuterana aerial parts were investigated to find its free radical scavenging principles. Hydroalcoholic fraction with IC50 value of 112.6 ±3.2 μg ml-1 in DPPH assay demonstrated the highest free radical scavenging a...
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It has been generally accepted that the primary mechanism of action of antianginal drugs is the improvement of the myocardial oxygen balance between supply and demand in the ischemic heart, by either an increase in coronary flow or a decrease in cardiac mechanical function, or both. Therefore, nitrates, b-adrenoceptor antagonists, and Ca channel blockers, which are thought to improve the myocar...
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ژورنال
عنوان ژورنال: Japanese Journal of Pharmacology
سال: 1993
ISSN: 0021-5198
DOI: 10.1016/s0021-5198(19)51716-4